Research Paper

Toxicity and Efficacy Study of Novel Herbal Formulation of Hadjoint® Tablets.

Cordeiro MC.

Asian J. Med. Pharm. Res., 9(2): 11-16, 2019; pii:S2252043019000002-9

Abstract

Osteoarthritis, one of the most common forms of arthritis is a cause of concern especially in women and the elderly age group. Alternative modes of treatment like herbal medicines are preferred, since conventional methods of treatment do not treat the underlying cause. HADJOINT® tablet, a novel herbal formulation was prepared by combining different plant extracts like Cissus quadrangularis, Moringa oleifera, Emblica officinalis and others. The aim of the study was to determine the toxicity and efficacy of the herbal formulation in adjuvant induced osteoarthritis in Wistar rats. The study found HADJOINT® to be non-toxic till 2000 mg/kg body weight. It also showed lowered levels of erythema, edema and limping indicating reduced arthritis. The absence of clinical signs of mortality or toxicity, changes in hematology and biochemical parameters on treatment implies safety and efficacy potential comparable to Diclofenac.

Keywords: Edema, Erythema, Osteoarthritis, Toxicity

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