Volume 2 : Issue 4, December2012

Table of Contents, 20 Dec 2012

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Article Information/
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Comparison of Oral and Injection Erythropoietin on Level of Hemoglobin Concentration in Premature Neonates: A Randomized Controlled Trials


AJMPR_B14


Original Research, B14
Molavi M, Mirjalili R, Nazemi A, Saadat H, Goodarzi R, Hamedi Y and Safa M.
Asian J. Med. Pharm. Res.,
2(4): 64-68, 2012

ABSTRACT: Preterm infants, often develop anemia which need for transfusion. Erythropoietin is effective in decreasing the number of transfusion needed in these infants. The aim of current study is to compare the efficacy of oral and injection erythropoietin in preterm neonates. Method: In a randomized controlled trail, 38 low birth weight (LBW) infants with gestational age ≤ 34 weeks who met the inclusion criteria and did not have exclusion criteria were selected. Neonates were divided in two groups of case and control. Control group received 250 µ/kg subcutaneous erythropoietin, three times a week and the case group received 1000 u/kg of oral erythropoietin three times a week. The two group were compared for the number of transfusion, hemoglobin, and hematocrit level in first, second, third and fourth week of study. Data was analyzed via SPSS® ver. 16 for Windows®. The two groups were similar in baseline characteristics. There were no significant difference between two groups in the number of transfusion (p=0.37); there were no significant different in quantity of hemoglobin in weeks one to four of study, between two groups (p>0.05). The mean basic Hemoglobin in the control was 10.52±2.4 and 11, 13±2.3 in case. At the fourth week, mean Hemoglobin was 8.73±1.12 in control and 8.89±1.6 in case. The mean basic hematocrit was 30.73±6.69 in control and 32.67±6.63 in case, and at the fourth week it was 26.84±3.66 in control and 26.64±4.7 in case. There were no significant difference between mean Hemoglobin and mean hematocrit in the beginning and week one to four. The reticulocyte count increases from 1.9 to 2.4 at the end if study. Oral and subcutaneous erythropoietin have similar effect; oral erythropoietin is less intensive and this method is suggested in the treatment of anemia of prematurity.
KEYWORDS: Anemia of prematurity, Erythropoietin, Transfusion 

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Study and Comparison of Anxiety and Depression as Predictors of Attention Deficit Hyperactivity Disorder in Primary School Children of Tehran


Original Research, B15
Zarei E., Mohammadi K. And Asadi Louyeh M.
Asian J. Med. Pharm. Res. 2(4): 69-73, 2012

ABSTRACT: Attention deficit / hyperactivity is a disorder in which hyperactivity, attention deficit and abrupt behaviors are more and more severe comparing to other children. 3 to 5% of children are having this disorder and it is more common and seen in boys. It is possible that in some, more symptoms of hyper-activeness, abrupt behaviors and in some attention deficit would be observed more. The main purpose of this paper is to study the relationship between Anxiety and depression as the factor causing attention deficit disorder / hyperactivity in children in primary schools. This paper will also study the differences between normal children and children having this disorder. With using descriptive statistics, absolute frequency percentage, cumulative frequency percentage, column chart, pie chart and also mean and standard deviation have been used for comparing the demographic characteristics. For testing hypotheses the multi-variables variance analysis (MANOVA) and logistic regression have been used. Due to the value of F-statistics equal to 116.348 and significant level of 0.00004, there is a significant difference between children with hyperactivity and attention deficit disorders and normal children regarding Anxiety and depression. Also it can be said that 83.9% of predictions for the group without ADHD disorder and 78.6% of predictions for the group with ADHD disorder are correct. In fact it can be said that generally our model has determined the individuals correctly around 81.3%. in logistic model the significance level of the depression variable is 0.00001 and for Anxiety it is 0.002 and both are them are less than 0.05. These results indicated that depression and Anxiety can predict the probability of children coming down with hyper-activity and attention deficit.
KEYWORDS: Anxiety, Depression, Hyperactivity, Attention deficit disorder

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The Effect of Group Cognitive Behavior Therapy in Children with Social Anxiety Disorder


Original Research, B16
Keramati K., Zargar Y., Naami A., Davodi I., Beshlide K.
Asian J. Med. Pharm. Res. 2(4): 74-76, 2012

ABSTRACT: The present study's aim was to examine the effect of group cognitive behavior therapy (GCBT) on children (8-12 year old) with social anxiety disorder. Participants (N =50) were between 8-12 years of age (M=10.02 years, SD=1.52). Main outcome was the targeted social anxiety disorder and symptoms. Results remission for social anxiety disorder and symptoms in experimental group were evident and statistically significant. In other hand remission from social anxiety due to GCBT was different between experimental and control group. Compare to control group outcomes weren't different in boys and girls. Consistent with past study's findings, this research provide further evidence benefits of GCBT for childhood social anxiety disorder.
KEYWORDS: Social anxiety disorder, Childhood, Group Cognitive Behavior Therapy

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 Study of Ethical Standards in Clinical Trial Research on Children

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Editorial Borad

Original Research, B17
Sajjadi H. and Nejatizade A.
Asian J. Med. Pharm. Res.
2(4): 77-79, 2012

ABSTRACT: Scientific studies have developed medical science field and consequently have left positive effects on promoting level of health and reduction of diseases in humans; study of the ethical considerations in clinical trial research on children is a very sensitive and important issue that deserves attention. The present paper discusses this issue in the clinical trial research on children. Fifty articles published on Scientific Information Database of Jahad Daneshgahi, encompassing the report of clinical trial research on children, were studied in terms of observance or nonobservance of the ethical codes (five ethical codes). The purposive sampling method was used to select the studies. According to the analysis, 40 items (80 percent), 4 items (8 percent), 6 items (12 percent), 23 items (46 percent) and all of them (100 percent) observed the ethical codes of one, two, three, four and five, respectively. Among the studied articles, one paper observed all the five ethical codes. With respect to the importance of ethical considerations, scientific journals and publications should pay more attention and inform authors of observing these considerations.
KEYWORDS:
Ethical Standards, Children, Clinical Trial

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