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Volume 6 (4); 25 December, 2016
Research Paper
Antibacterial Activities of Benzoin Thiosemicarbazone and Its Complexes with Co(II) and Ni(II).
Mohammad Zakir H, Jesmin M and Mohsin Ali ShM.
Asian J. Med. Pharm. Res., 6(4): 32-40, 2016.; pii:S2252043016000006-6
Abstract
The schiff base benzoin thiosemicarbazone and two of its complexes Co(BTSC)2 and Ni(BTSC)2 were used to study their antibacterial activities against some pathogenic bacterial strains by disc diffusion method. Benzoin thiosemicarbazone was synthesized by refluxed standard solutions of benzoin and thiosemicarbazone in 1:1 molar ratio for a period of 3-4 hours. The crystals of benzoin thiosemicarbazone were obtained after partial evaporation of the resulting solution and cooling to room temperature. The complexes were similarly obtained by refluxing the standard solutions of BTSC and metal acetates in 2:1 molar ratio. The antibacterial activities of all the compounds were studied in vitro by disc diffusion methods. The potency was justified by measuring the zone of inhibition in mm on a previously inoculated nutrient broth and incubated for 24 hours at 370C. All of the compounds were found to possess different degrees of antibacterial activity but Co(II)-Benzoin thiosemicarbazone complex showed a better antibacterial activity against both gram positive and gram negative bacteria. It showed 29 mm zone of inhibition against E.Coli bacteria at the dose of 600µg/disc whereas the standard drug Kanamycin showed 30 mm zone of inhibition against the same bacteria at the dose of 30µg/disc. All of these three compounds were found to possess cytotoxic effect. Minimum inhibitory concentration and minimum bactericidal concentration of these compounds were also determined.
Keywords: Antibacterial activity, Minimum inhibitory concentration, Minimum bactericidal concentration, Brine shrimp lethality
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Research Paper
The Effects of Walnut Consumption on Plasma Antioxidant Capacity.
Arslan FD, Koseoglu MH, Semerci T, Atay A.
Asian J. Med. Pharm. Res., 6(4): 41-45, 2016.; pii:S2252043016000007-6
Abstract
Epidemiological studies have demonstrated the benefits of walnut consumption, attributed in part to their fatty acid profile, rich in unsaturated fatty acids, and also to walnut-derived antioxidant polyphenols, on human health. The purpose of the present study was to assess the acute effect of walnut ingestion on plasma antioxidant status in healthy volunteers. Thirteen healthy volunteers (24.3 ± 6.2 years of age) were participated in the study. After fasting blood was obtained, each volunteer consumed a certain amount of walnut and blood samples were taken at the 3rd hour. Total antioxidant capacity and lipid parameters were measured in the plasma. Total antioxidant capacity was significantly higher at the 3rd hour compared to the basal value. This result supports the hypothesis that walnut ingestion increases total antioxidant capacity in plasma. Conducting new epidemiologic studies with large a population consuming walnut would be useful to get more insight on this subject.
Keywords: Walnut, Antioxidant capacity, Reactive oxygen species
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Research Paper
Changes in Serum Levels of Vitamin B12, Folic acid and Homocysteine in Patients with Type 2 Diabetes before and after Treatment with Metformin.
Karimi F and Ranjbar Omrani Gh.
Asian J. Med. Pharm. Res., 6(4): 46-52, 2016.; pii:S2252043016000008-6
Abstract
Diabetes mellitus is one of the most common chronic disorders in the world. Previous investigations have suggested that metformin, as a key treatment option in type 2 diabetes, may lead to hyperhomocysteinemia through decreasing the levels of vitamin B12 and folic acid. In this clinical trial, 55 patients with type 2 diabetes who referred to two clinics of Shiraz University of Medical Sciences participated. At first, the participants followed diet regimen alone for 3 months and then in the next 3 months they were treated by metformin. Serum levels of vitamin B12, folic acid and homocysteine were checked before and after the diet alone and metformin consumption, then they were compared. After 3 months of diet regimen alone the levels of vitamin B12, folic acid and homocysteine did not show statistically (P≤0.05) significant differences. However, three months of treatment with metformin resulted in significantly higher levels of homocysteine (P=0.001) although serum levels of folic acid and vitamin B12 did not change significantly again (P=0.1 and P=0.4, respectively). Our data provided no support for this hypothesis that metformin consumption increases homoysteine secondary to folate and /or B12 deficiency.
Keywords: Type 2 diabetes, Metformin, Folic acid, Vitamin B12, Homocysteine
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Research Paper
Oral Ibuprofen for Closure of Patent Ductus Arteriosus in Full-term Neonates' Aged 20-28 days.
Noori NM, Rajaei S, Teimouri A, Naderi S and Hashemi S.
Asian J. Med. Pharm. Res., 6(4): 53-57, 2016.; pii:S2252043016000009-6
Abstract
Patent ductus arteriosus accounts for about 10% of congenital heart disease. Although surgical or catheter closure of patent ductus arteriosus is safe but with some complications and not possible in anywhere. Efficacy of ibuprofen for patent ductus arteriosus closure is shown in preterm neonates. The aim of the current study was to evaluate the efficacy and safety of oral ibuprofen in full- term neonates after the first days of life. This study was a randomized clinical trial on 20-28-day term infants with confirmed patent ductus arteriosus. The sample size was 40 infants divided randomly in case (n = 20) and control group (n = 20). The case group received ibuprofen suspension initially with a dosage of 10 mg/kg, then two 5 mg/kg doses 12 hours apart. If ductal closure did not occur, a second course was repeated after one week. Case group was assessed by adverse effects and complications. The control group received no medication or placebo. To confirm patent ductus arteriosus, diagnosis and follow up by 2 dimensional color Doppler echocardiography was performed. Data was analyzed using SPSS version 16 software. There was no significant difference between the two groups in age, weight, sex, and patent ductus arteriosus size. There wasn’t any ductal closure in case group after one course of treatment. Patent ductus arteriosus was closed in 75% of patients in treated group after second course, but no spontaneous closure was reported in control group (P < 0.001). None of the patients reported drug complication. The current study indicated that two courses of treatment by oral ibuprofen seem effective with no complications in closing patent ductus arteriosus of full-term infants' aged 20-28 days. However, further research in this field is recommended.
Keywords: Patent ductus arteriosus, Ibuprofen, Full term, Neonates, Medical treatment
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